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Publications

08/13/2019

Hajj R, et al: Baclofen, Naltrexone and Sorbitol all contribute to the efficacy of PXT3003 in CMT1A Rats. EMJ Neurol, 2019;7[1]:47-49. AR6

04/13/2019

Bouchenaki H, et al: Pharmacological management of neuropathic pain. Therapies 2019, https://doi.org/10.1016/j.therap.2019.04.00

01/16/2019

Prukop T, et al: Early short-term PXT3003 combinational therapy delays disease onset in a transgenic rat model of Charcot-Marie-Tooth disease 1A (CMT1A). PLoS One. 2019 Jan 16;14(1)

09/25/2018

Hajj R: Parkinson Disease Therapies and Drugs. Pathology, Prevention and Therapeutics of Neurodegenerative Disease, Chapter 13, pp 151-158

02/02/2018

Duchesne M, et al: Skin Biopsy Findings in Patients With CMT1A: Baseline Data From the CLN-PXT3003-01 Study Provide New Insights Into the Pathophysiology of the Disorder. J Neuropathol Exp Neurol. 2018 Feb 2;1-8

11/01/2017

Touchon J, et al: Direct double-blind analysis arguing for synergistic therapeutic effect of a fixed low-dose combination of acamprosate and baclofen in patients with AD. 2017 Nov 1-4. CTAD Poster #LBP32BIS

01/17/2017

Wang W, et al: A Rasch Analysis of the Charcot-Marie-Tooth Neuropathy Score (CMTNS) in a Cohort of Charcot-Marie-Tooth Type 1A Patients. PLoS One. 2017 Jan 17;12(1)

07/07/2016

Attarian S, et al: Erratum to: An exploratory randomized double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A. Orph J Rare Dis. 2016 Jul 7;11.92

07/05/2016

Toulorge D, et al : Molecular changes in the postmortem parkinsonian brain. J Neurochem. 2016 Oct;139 Suppl 1:27-58

11/06/2015

Hajj R, et al: Combination of acamprosate and baclofen as a promising therapeutic approach for Parkinson's disease. Scientific Reports (Nature) 2015 Nov 6:16084

06/13/2015

Mandel J, et al: A meta-analysis of randomized doubleblind clinical trials in CMT1A to assess the change from baseline in CMTNS and ONLS scales after one year of treatment. Orph J Rare Dis. 2015 Jun 13;74

01/08/2015

Chumakov I, et al: Combining two repurposed drugs as a promising approach for Alzheimer’s disease therapy. Scientific Reports (Nature) 2015 Jan 8;7608

12/18/2014

Attarian S, et al: An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of Baclofen, Naltrexone and Sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A. Orph J Rare Dis. 2014 Dec 18:199

12/10/2014

Chumakov I, et al: Polytherapy with a combination of three repurposed drugs (PXT3003) down-regulates Pmp22 over-expression and improves myelination, axonal and functional parameters in models of CMT1A neuropathy. Orph J Rare Dis. 2014 Dec 10;201

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